M8083147
RubratoxinA , 98% , 22467-31-8
| Pack Size | Price | Stock | Quantity |
| 250μg | RMB4628.00 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 210-214℃ (decomposition) |
| storage temp. | Store at -20°C |
| solubility | Acetonitrile: soluble; DMSO: soluble |
| form | A powder |
| color | White |
Description and Uses
Rubratoxin A is a natural mycotoxin and competitive inhibitor of protein phosphatase 2A (PP2A; IC50 = 170 nM). It has no significant effect on several other phosphatases, including PP1, PP2B, and protein tyrosine phosphatase 1B. Rubratoxin A drives overphosphorylation of PP2A substrate proteins in cultured cells treated for three hours at 20 μM. It causes suppression of tumor metastasis and reduction of primary tumor volume in mouse xenografts.
Rubratoxin A is a potent and selective competitive PP2A inhibitor.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazardous Substances Data | 22467-31-8(Hazardous Substances Data) |
