(+)-Rugulosin , 98% , 23537-16-8
| Pack Size | Price | Stock | Quantity |
| 1mg | RMB2361.60 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 293℃ (decomposition) |
| Boiling point: | 535.95°C (rough estimate) |
| Density | 1.3164 (rough estimate) |
| refractive index | 1.5376 (estimate) |
| storage temp. | Store at -20°C |
| solubility | DMSO: Soluble; Ethanol: Soluble; Methanol: Soluble |
| form | A solid |
| pka | 4.20±1.00(Predicted) |
| IARC | 3 (Vol. 40, Sup 7) 1987 |
| EPA Substance Registry System | 5H,6H-6,13a,5a,14-[1,2,3,4]Butanetetraylcycloocta[1,2-b:5,6-b']dinaphthalene-5,8,13,16(14H)-tetrone, 1,7,9,15,17,20-hexahydroxy-3,11-dimethyl-, (5aS,6R,13aS,14R,17S,18R,19R,20S)- (23537-16-8) |
Description and Uses
(+)-Rugulosin is a pigment and mycotoxin produced by certain fungi. It inhibits HIV-1 integrase activity with IC50 values of 19 and 25 μM in coupled and strand transfer assays, respectively. It also inhibits ribonuclease H in rat liver by 83% at a concentration of 157 μM and ribonucleases H1, H2, and H3 in T. pyriformis by 100, 99, and 100%, respectively, at a concentration of 313 μM. (+)-Rugulosin leads to hepatic injury and liver cell hyperplasia in mice when administered in the diet. It is cytotoxic to insect cells but not mammalian C6/36, L929, and HepG2 cells (ID50s = 1.2, >200, 23.7, and >200 μg/ml, respectively).
Rugulosin (+ form) is an intense yellow pigment produced by Penicillium and Aspergillus.
Safety
| HS Code | 29419000 |
