N-acetyl-2-carboxyBenzenesulfonamide , 98% , 849067-18-1

CAS NO.：849067-18-1

Empirical Formula: C9H9NO5S

Molecular Weight: 243.24

MDL number:

PRODUCT Properties

• Melting point: 178-180 °C
• Density: 1.463±0.06 g/cm3(Predicted)
• storage temp.: Store at -20°C
• solubility: ≤30mg/ml in ethanol;30mg/ml in DMSO;30mg/ml in dimethyl formamide
• form: crystalline solid
• pka: 2.79±0.36(Predicted)

Description and Uses

N-acetyl-2-carboxy Benzenesulfonamide is a structural analog of aspirin that acts as a non-selective inhibitor of cyclooxygenase (COX) with a COX-2 selectivity index of 0.23. In vitro studies showed that N-acetyl-2-carboxy Benzenesulfonamide is a more potent inhibitor of COX-1/COX-2 with IC₅₀ values of 0.06 μM and 0.25 μM, respectively, than aspirin with IC₅₀ values of 0.35 μM and 2.4 μM, respectively.

N-Acetyl-2-carboxybenzenesulfonamide is an orally active COX-1 and COX-2 inhibitor with IC50s of 0.06 μM and 0.25 μM, respectively. N-Acetyl-2-carboxybenzenesulfonamide shows anti-inflammatory activity[1].

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P321-P362+P364-P332+P313-P337+P313-P403+P233-P405-P501