17β-hydroxyWortmannin , 98% , 58053-83-1

Synonym(s):
PI 3-K Inhibitor XI, HWT - CAS 58053-83-1 - Calbiochem;Wortmannin, 17β-Hydroxy, LY 301497, mTOR Inhibitor VIII

CAS NO.：58053-83-1

Empirical Formula: C23H26O8

Molecular Weight: 430.45

MDL number:

PRODUCT Properties

• Boiling point: 615.4±55.0 °C(Predicted)
• Density: 1.39±0.1 g/cm3(Predicted)
• storage temp.: +2C to +8C
• solubility: DMF: 3 mg/ml; DMF:PBS (pH 7.2) (1:9): 0.1 mg/ml; DMSO: 2.5 mg/ml; Ethanol: 0.15 mg/ml
• form: Off-white solid
• pka: 14.49±0.70(Predicted)
• color: off-white

Description and Uses

17β-hydroxy Wortmannin is an analog of wortmannin. It irreversibly binds phosphoinositide 3-kinase (PI3K) and potently blocks fMLP-stimulated respiratory burst in neutrophils (IC₅₀ = 5 nM). 17β-hydroxy Wortmannin inhibits recombinant PI3K and mTOR (IC₅₀ = 2.7 and 193 nM, respectively) and prevents the growth of LNCap prostate cancer cells (IC₅₀ = 1.46 μM). The 17-hydroxyl group has been used to further modify this compound, e.g., by pegylation and conjugation with rapamycin.

17β-Hydroxywortmannin (Wortmannin-17β-ol) is an orally active inhibitor for phosphatidylinositol-3-kinase (PI-3-kinase) with an IC50 of 0.5 nM, suppresses the osteoclast resorption with an IC50 of 10 nM[1]. 17β-Hydroxywortmannin exhibits antitumor activity[2].

Safety

• Symbol(GHS): GHS06
• Signal word: Danger
• Hazard statements: H300+H310+H330
• Precautionary statements: P260-P262-P264-P270-P271-P280-P284-P301+P310-P330-P302+P352-P304+P340-P320-P361+P364-P403+P233-P405-P501