3-Deazauridine(NSC126849) , 98% , 23205-42-7
CAS NO.：23205-42-7
Empirical Formula: C10H13NO6
Molecular Weight: 243.21
MDL number: MFCD00006522
EINECS: 245-488-8
| Pack Size | Price | Stock | Quantity |
| 5mg | RMB908.80 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 233-235°C |
| Boiling point: | 569.2±50.0 °C(Predicted) |
| Density | 1.718±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | DMSO (Slightly), Methanol (Slightly), Water (Slightly) |
| form | Solid |
| pka | 4.50±1.00(Predicted) |
| color | White to Pale Beige |
| InChI | InChI=1/C10H13NO6/c12-4-6-8(15)9(16)10(17-6)11-2-1-5(13)3-7(11)14/h1-3,6,8-10,12-13,15-16H,4H2/t6-,8-,9-,10-/s3 |
| InChIKey | CBOKZNLSFMZJJA-FNMQVXAUNA-N |
| SMILES | [C@@H]1([C@H](O)[C@H](O)[C@@H](CO)O1)N1C=CC(O)=CC1=O |&1:0,1,3,5,r| |
| LogP | -1.693 (est) |
Description and Uses
3-Deazauridine is a structural analog of uridine that inhibits the biosynthesis of Cytidine-5'-Triphosphate by competitive inhibition of Cytidine Triphosphate synthetase, which is considered to be the primary mode of action of this nucleoside analog. This compound has been shown to possess in vitro activity against leukemia L1210 tumor cells, Ehrlich ascites tumor cells, Escherichia coli, and Streptococcus faecium. Despite a paucity of clinical attention given to this drug as a single agent, it has generated much enthusiasm as a biological response modulator because of its synergistic effect with several antitumor agents, including Cytosine Arabinoside, 5-aza-2'-deoxycytidine, 5-azacytidine, thymidine and D-galactosamine. However, only the cytosine arabinoside/3-Deazauridine combination has been explored clinically[1-2].
Antimetabolite antiviral dosing regimen for hepatitis C virus or flaviviridae therapy.
Safety
| RTECS | UV1148000 |
