8-isoProstaglandinE1 , 98% , 21003-46-3

CAS NO.：21003-46-3

Empirical Formula: C20H34O5

Molecular Weight: 354.48

MDL number: MFCD00065736

PRODUCT Properties

• Melting point: 77-79 °C(Solv: ethyl acetate (141-78-6); hexane (110-54-3))
• Boiling point: 529.3±50.0 °C(Predicted)
• Density: 1.131±0.06 g/cm3(Predicted)
• storage temp.: Store at -20°C
• solubility: DMF: >100 mg/ml (from PGE1); DMSO: >50 mg/ml (from PGE1); Ethanol: >50 mg/ml (from PGE1); PBS pH 7.2: >1.6 mg/ml (from PGE1)
• form: A light yellow crystalline solid
• pka: 4.77±0.10(Predicted)

Description and Uses

Isoprostanes are a family of prostanoid molecules of non-cyclooxygenase origin. 8-iso Prostaglandin E₁ (8-iso PGE₁) is an isoprostane which is found in human semen at levels of 7 μg/ml. It is a pulmonary vasoconstrictor in anesthetized dogs with a potency similar to PGF_2α.

8-Isoprostaglandin E1 has vasodilatory and electrophysiological actions porcine coronary artery. It also inhibits acetylcholine release from parasympathetic nerves innervating guinea-pig trachea mediation by prostanoid EP3 receptors.