Tacrolimus-13C,d2 , ≥98% , 1356841-89-8
Pack Size | Price | Stock | Quantity |
1mg | RMB11232.00 | In Stock |
|
others | Enquire |
PRODUCT Properties
storage temp. | -70°C |
solubility | Chloroform: Slightly Soluble,Methanol: Slightly Soluble |
form | A solid |
color | White to yellow |
Description and Uses
FK-506-13C-d2 contains two deuterium atoms located on the carbon-13 bond. It is intended for use as an internal standard for the quantification of FK-506 by GC- or LC-MS. FK-506 is a potent, clinically-useful immunosuppressant in the same molecular class as cyclosporin A and rapamycin. Its mechanism of action involves the formation of a high affinity complex (Ki = 0.2 nM) with FK-
A labelled immunosuppressant that blocks T cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2. Shown to inhibit the activity of FK-506 binding protein, thereby reversing its effects on sarcoplasmic reticulum Ca+2 release. A representative lot contained a distribution of 20% d-1, 40% d-2 and 20% d-3.
Safety
Symbol(GHS) | ![]() GHS06 |
Signal word | Danger |
Hazard statements | H301 |
Precautionary statements | P264-P270-P301+P310-P321-P330-P405-P501 |
RIDADR | UN 1648 3 / PGII |