Azido-PEG4-CH2-Boc , 98% , 864681-04-9
CAS NO.：864681-04-9
Empirical Formula: C14H27N3O6
Molecular Weight: 333.381
MDL number: MFCD20134125
| Pack Size | Price | Stock | Quantity |
| 25mg | RMB704.00 | In Stock |
|
| 100mg | RMB1936.00 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| solubility | Soluble in DMSO, DCM, DMF |
| form | Liquid |
| color | Colorless to light yellow |
Description and Uses
Azido-PEG4-CH2CO2-t-butyl ester is a PEG reagent containing an azide group and a t-butyl protected carboxyl group. The azide group enables Click Chemistry. The protected carboxyl group (COOH) prevents self coupling or polymerization under standard acid/amine or acid/hydroxyl coupling conditions. t-butyl ester can be deprotected by acidic or basic hydrolysis. The hydrophilic PEG spacer increases solubility in aqueous media.
Azido-PEG4-CH2-Boc is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Azido-PEG4-CH2-Boc is also a PEG- and Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[2]. Azido-PEG4-CH2-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
