Karacoline , ≥98% , 39089-30-0

CAS NO.：39089-30-0

Empirical Formula: C22H35NO4

Molecular Weight: 377.52

MDL number: MFCD00285963

PRODUCT Properties

• Melting point: 185-186℃ (acetone )
• Boiling point: 540.2±50.0 °C(Predicted)
• Density: 1.30±0.1 g/cm3 (20 ºC 760 Torr)
• storage temp.: 2-8°C
• form: Solid
• pka: 13.80±0.70(Predicted)
• color: White to off-white

Description and Uses

A second atisine base found in the tubers of Aconitum karacolicum, the structure has been elucidated from chemical and spectroscopic data. Oxidation with KMn04 gives anhydroepoxykaracoline. The alkaloid furnishes a triacetyl deriva_x0002_tive which, after pyrolysis and hydrolysis, yields acetyldemethylisopyrokaracoline.

Karacoline is an Aconitane (A189875) derivative, which is a neurotoxin which activates tetrodotoxin-sensitive Na+ channels, inducing presynaptic depolarization, thus blocking the nerve action potential which, in turn, blocks the release of neurotransmitters and decreases the end plate potential at the neuromuscular junction.

Safety

• RTECS: AR5569480