M7153958
CathepsinL-IN-2 , ≥98% , 108005-94-3
Synonym(s):
Cathepsin L Inhibitor I - CAS 108005-94-3 - Calbiochem;Z-FF-FMK
CAS NO.：108005-94-3
Empirical Formula: C27H27FN2O4
Molecular Weight: 462.51
MDL number: MFCD03453604
| Pack Size | Price | Stock | Quantity |
| 10mg | RMB1280.00 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Boiling point: | 707.5±60.0 °C(Predicted) |
| Density | 1.214±0.06 g/cm3(Predicted) |
| storage temp. | −20°C |
| solubility | DMSO: 20mM |
| pka | 11.07±0.46(Predicted) |
| form | solid |
| color | White to off-white |
Description and Uses
Cathepsin L-IN-2 ((Rac)-Z-Phe-Phe-FMK) is an isomer of the Cathepsin L/B inhibitor Z-Phe-Phe-FMK (HY-141867), with an IC50 of 15 μM for cathepsin L. Z-Phe-Phe-FMK irreversibly blocks the proteolytic function of cathepsins by covalently binding to the cysteine residues in the active center of the enzyme. Cathepsin L-IN-2 and Z-Phe-Phe-FMK can be used to study neurodegenerative diseases (such as GRN-related frontotemporal dementia) and cancer invasion and metastasis.
Safety
| WGK Germany | 3 |