Theaflavin3,3''-digallate , Analysis of the control products,> 98% , 30462-35-2

Synonym(s):
(S)-5-Hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-dodecanone;8-Gingerol

CAS NO.：30462-35-2

Empirical Formula: C43H32O20

Molecular Weight: 868.71

MDL number: MFCD06797365

PRODUCT Properties

• Melting point: 226～230℃
• Boiling point: 1352.6±65.0 °C(Predicted)
• Density: 1.97±0.1 g/cm3(Predicted)
• storage temp.: Store at -20°C, sealed storage, away from moisture and light
• solubility: DMSO : 41.67 mg/mL (47.97 mM; Need ultrasonic)
• form: Solid
• pka: 6.55±0.20(Predicted)
• color: Red-purple
• InChIKey: ZEASWHWETFMWCV-ISBUVJFSSA-N
• CAS DataBase Reference: 30462-35-2

Description and Uses

Theaflavin-3,3''-digallate (TFDG) is a major polyphenol found in black tea with diverse biological activities. It has antioxidant activity, inhibiting the formation of superoxide radicals, singlet oxygen, hydrogen peroxide, and hydroxyl radicals in vitro (IC₅₀s = 26.7, 0.83, 0.39, and 25.07 μmol/L, respectively). It also reduces hydroxyl radical-induced damage to plasmid DNA. TFDG (12.5-50 μM) prevents LPS-induced release of TNF-α, IL-1β, and IL-6, expression of JNK and p38, and nuclear translocation of NF-κB in RAW 264.7 cells. In vivo, TFDG reduces serum levels of TNF-α, IL-1β, and IL-6 and decreases pulmonary edema, pulmonary congestion, and thickening of the alveolar wall in a mouse model of LPS-induced acute lung injury. It also inhibits osteoclast formation, polarization, and osteoclastic bone resorption in vitro and reduces titanium particle-induced bone erosion and the number of mature osteoclasts in mice in a dose-dependent manner.

Theaflavin 3,3′-digallate may be used as an analytical reference standard for the quantification of the analyte in tea samples using high-performance liquid chromatography with tandem mass spectrometric detection.

Safety

• WGK Germany: 3
• HS Code: 29329990