Rosiptor , ≥98% , 782487-28-9

CAS NO.：782487-28-9

Empirical Formula: C20H35NO2

Molecular Weight: 321.5

MDL number: MFCD31619271

PRODUCT Properties

• Boiling point: 451.6±45.0 °C(Predicted)
• Density: 1.07±0.1 g/cm3(Predicted)
• storage temp.: Store at -20°C
• solubility: DMSO : 150 mg/mL (466.56 mM)
• pka: 15.05±0.10(Predicted)
• form: Solid
• color: White to off-white
• InChI: InChI=1S/C20H35NO2/c1-13-4-5-17-16(11-21)18(7-9-19(13,17)2)20(3)8-6-15(23)10-14(20)12-22/h14-18,22-23H,1,4-12,21H2,2-3H3/t14-,15+,16+,17+,18+,19-,20+/m1/s1
• InChIKey: MDEJTPWQNNMAQF-BVMLLJBZSA-N
• SMILES: [C@H]1(CO)C[C@@H](O)CC[C@@]1([C@H]1CC[C@@]2(C)[C@]([H])([C@@H]1CN)CCC2=C)C

Description and Uses

Rosiptor (AQX-1125) is a selective and orally active phosphatase SHIP1 activator with anti-inflammatory effects. It inhibits Akt phosphorylation, inflammatory mediator production and leukocyte chemotaxis in vitro.

Rosiptor has been used in trials studying the treatment of COPD, Atopic Dermatitis, Interstitial Cystitis, and Bladder Pain Syndrome.