M5268335
Ro4584820 , 99% , 741713-40-6
CAS NO.：741713-40-6
Empirical Formula: C18H21F2N5O4S
Molecular Weight: 441.45
MDL number: MFCD09970629
| Pack Size | Price | Stock | Quantity |
| 1mg | RMB2201.60 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Boiling point: | 703.7±70.0 °C(Predicted) |
| Density | 1.49 |
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO |
| form | crystalline solid |
| pka | 4.22±0.10(Predicted) |
| color | White to off-white |
Description and Uses
Cyclin-dependent kinases (Cdks) are critical positive regulators of cell cycle progression and cellular transcription whose dysregulation can lead to the development of cancer. R547 is a diaminopyrimidine compound that inhibits Cdk1/cyclin B, Cdk2/cyclin E, and Cdk4/cyclin D1 (Kis = 1-3 nM). It is inactive against a panel of more than 120 unrelated kinases (Kis > 5 μM). R547 inhibits tumor cell proliferation (IC50s ≤ 0.6 μM in vitro), inducing cell cycle arrest at G1 and G2 phases and apoptosis as well as reducing phosphorylation of the retinoblastoma protein. It also demonstrates antitumor activity in vivo in various human tumor xenograft models.
