PRODUCT Properties
| Melting point: | 217-219° |
| alpha | D18 +74.7° (c = 0.4 in chloroform); D20 +87.3° (in chloroform) |
| Boiling point: | bp18 282° |
| Density | 1.0434 (rough estimate) |
| refractive index | 1.4800 (estimate) |
| storage temp. | Store at -20°C |
| solubility | DMSO: soluble,Water: soluble |
| pka | 4.68±0.60(Predicted) |
| form | Solid |
| color | White to off-white |
| LogP | 6.731 (est) |
Description and Uses
Pimaric acid is a resin acid that has been found in A. cordata and various pines. It reduces mRNA expression, protein levels, and promoter activity of matrix metalloproteinase-9 (MMP-9) in TNF-α-stimulated human aortic smooth muscle cells (HASMCs) in a concentration-dependent manner when used at concentrations ranging from 5 to 20 μM. Pimaric acid (10-20 μM) reduces nuclear expression and binding of the transcription factors NF-κB and AP-1 to the MMP-9 promoter in HASMCs. Pimaric acid also reduces TNF-α-induced HASMC migration to control levels when used at a concentration of 20 μg/ml.
A novel activators of large-conductance Ca2+-activated K+ channel α-subunit.
