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M4985535

Picrotoxin? , >94% , 124-87-8

Synonym(s):
Cocculin;Picrotoxin, Anamirta cocculin - CAS 124-87-8 - Calbiochem

CAS NO.:124-87-8

Empirical Formula: C30H34O13

Molecular Weight: 602.58

MDL number: MFCD00074824

EINECS: 204-716-6

Update time: 2022-07-08

PRODUCT Properties

Melting point: 203 °C(lit.)
alpha  D16 -29.3° (c = 4 in abs ethanol)
Boiling point: 571.75°C (rough estimate)
Density  1,28 g/cm3
refractive index  1.6000 (estimate)
storage temp.  Store at RT
solubility  ethanol: 50 mg/mL, clear to slightly hazy
form  powder
color  white to light yellow
Water Solubility  4.083g/L(room temperature)
Merck  14,7415
BRN  3894406

Description and Uses

Picrotoxin, also known as cocculin, appears as white to light beige crystalline material. It is isolated from Cocculus indicus (Fructus cocculi), fishberries, or Indian berries. Picrotoxin is a colourless, flexible, shining, prismatic crystals, or a micro-crystalline powder. It is odourless, has a very bitter taste, and is permanent in the air. Picrotoxin is soluble in hot water, readily soluble in strong ammonia water, and in aqueous solutions of sodium hydroxide, soluble in dilute acids, and alkalis as well as in glacial acetic acid, sparingly soluble in chloroform and very slightly soluble in cold water and alcohol. Picrotoxin is stable under normal temperatures and pressures and decompose when exposed to light. Picrotoxin is incompatible with strong oxidising agents, strong acids, strong bases, light.

Picrotoxin has been used:

  • as non-competitive antagonist for the γ-aminobutyric acid (GABAA) for studying synchronized burst (SB) dynamics
  • as a component of extracellular saline for blocking glutamate and acetylcholine receptors in neurons
  • as a component of artificial cerebrospinal fluid (ACSF) for voltage-clamp recordings studies in dissociated cortical neurons

Safety

Symbol(GHS) 
GHS06
Signal word  Danger
Hazard statements  H300
Precautionary statements  P264-P270-P301+P310+P330-P405-P501
Hazard Codes  T+,T,N
Risk Statements  28-52/53
Safety Statements  28-36/37/39-45-61
RIDADR  UN 3462 6.1/PG 2
WGK Germany  3
RTECS  TJ9100000
8-10
Hazard Note  Very Toxic
HazardClass  6.1(a)
PackingGroup  I
HS Code  29322985
Toxicity LD50 i.p. in mice: 7.2 mg/kg (Setnikar)

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