PRODUCT Properties
| Melting point: | 280 °C (dec.)(lit.) |
| storage temp. | room temp |
| Boiling point: | 741.8±60.0 °C(Predicted) |
| Density | 2.96±0.1 g/cm3(Predicted) |
| pka | 7.03±0.20(Predicted) |
| form | powder |
| color | pink to red |
| λmax | 557 nm |
| ε(extinction coefficient) | ≥10000 at 317-323nm ≥30000 at 516-522nm ≥95000 at 554-560nm |
| EPA Substance Registry System | Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 4,5,6,7-tetrachloro-3',6'-dihydroxy-2',4',5',7'-tetraiodo- (4159-77-7) |
Description and Uses
Rose bengal lactone is a potent inhibitor of human metabolism that binds to the proteasome pathway and inhibits the polymerization of tubulin. It has been shown to bind with high affinity to microtubules and inhibit their assembly, which leads to cell death. Rose bengal lactone also binds with high affinity to potassium ion, which may contribute to its anti-cancer effects. This compound has also been found to be an effective inhibitor of goiters in rats by binding with aliphatic hydrocarbons such as cholesterol.
Biological stain; colorant for inks, cellulosics, foods, cosmetics, medicine (diagnostic aid).
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-37/39 |
| WGK Germany | 3 |
