Novobiocin , 95% , 303-81-1

Synonym(s):
Benzamide, N-[7-[[3-O-(aminocarbonyl)-6-deoxy-5-C-methyl-4-O-methyl-?-l-lyxohexopyranosyl]oxy]-4-hydroxy-8-methyl-2-oxo-2H-1-benzopyran-3-yl]-4-hydroxy-3-
(3-methyl-2-butenyl), monohydrate;Streptonivicin

CAS NO.：303-81-1

Empirical Formula: C31H36N2O11

Molecular Weight: 612.62

MDL number:

EINECS: 206-146-3

PRODUCT Properties

• Melting point: 170-172 °C
• alpha: D24 -63.0° (c = 1 in ethanol)
• Boiling point: 657.29°C (rough estimate)
• Density: 1.3448
• refractive index: 1.5800 (estimate)
• storage temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• solubility: DMSO (Slightly), Methanol (Slightly)
• form: Solid
• pka: pKa1 4.3; pKa2 9.1(at 25℃)
• color: White to Pale Yellow

Description and Uses

Novobiocin (Albamycin, Cathamycin, Spheromycin) is an aminocoumarin antibiotic originally isolated from Streptomyces niveus in the Upjohn Research Laboratories and initially was given the generic name of ‘streptonivicin’ . It was also isolated almost simultaneously in other laboratories, and was given several other names. Novobiocin inhibits the GyrB subunit of DNA gyrase and is primarily active against Gram-positive microorganisms. It was used under the trade name Albamycin and was withdrawn from the market in the US. Its latest use included eradication of methicillin-resistant Staphylococcus aureus (MRSA) and other resistant microorganisms. In addition, it has been applied in cancer therapy.

Novobiocin is an aminocoumarin antibiotic used in the treatment of Staphylococcus epidermis.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H317
• Precautionary statements: P280-P301+P312+P330
• WGK Germany: 3
• HS Code: 2941906000