NalmefeneHydrochloride , 98% , 58895-64-0

CAS NO.：58895-64-0

Empirical Formula: C21H25NO3.ClH

Molecular Weight: 375.89

MDL number:

EINECS: 232-572-4

PRODUCT Properties

• Melting point: 180-185°
• storage temp.: Desiccate at RT
• solubility: Soluble in Water (up to 25 mg/ml).
• pka: 7.63(at 25℃)
• form: solid
• color: White
• Stability: Stable for 2 years from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 1 month.

Description and Uses

Nalmefene hydrochloride has been introduced in the U.S.A. for opioid reversal following surgery, and in the reversal of opioid overdoses and epidurally administered narcotics. Nalmefene is an opioid antagonist that inhibits respiratory, analgesic and subjective effects of opioids. It has a higher potency, a longer duration of action, and superior bioavailability than the structurally related naltrexone. Nalmefene has a wide spectrum of biological activity and is in clinical trials for the treatment of interstitial cystitis, recalcitrant pruritus of cholestasis, stroke, rheumatoid arthritis, shock, CNS trauma, and alcoholism. Studies indicate that nalmefene does not induce morphine-like effects and has no apparent abuse potential.

Nalmefene Hydrochloride is a structural analog of Naltrexone (N285780) with opiate antagonist activity used in pharmaceutical treatment of alcoholism. Other pharmacological applications of this compound aim to reduce food cravings, drug abuse and pulmonary disease in affected individuals. Used as an opioid-induced tranquilizer on large animals in the veterinary industry. Narcotic antagonist

Safety

• Symbol(GHS): GHS07,GHS08
• Signal word: Danger
• Hazard statements: H312-H317-H302-H332-H334
• Precautionary statements: P261-P272-P280-P302+P352-P333+P313-P321-P363-P501-P264-P270-P301+P312-P330-P501-P261-P271-P304+P340-P312-P280-P302+P352-P312-P322-P363-P501-P261-P285-P304+P341-P342+P311-P501