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M4251453

Nebivolol , 98% , 99200-09-6

CAS NO.:99200-09-6

Empirical Formula: C22H25F2NO4

Molecular Weight: 405.43

MDL number: MFCD00865796

Pack Size Price Stock Quantity
10mg RMB896.00 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Boiling point: 600.5±55.0 °C(Predicted)
Density  1.309±0.06 g/cm3(Predicted)
storage temp.  2-8°C(protect from light)
solubility  DMSO (Slightly), Methanol (Slightly, Heated)
form  Solid
pka 14.29±0.20(Predicted)
color  White to Off-White
InChIKey KOHIRBRYDXPAMZ-AWIIVWKDNA-N
SMILES C([2H])([2H])([C@H](O)[C@@]1([H])CCC2C=C(C=CC=2O1)F)NC([2H])([2H])[C@H](O)[C@]1([H])CCC2C=C(C=CC=2O1)F |&1:3,5,21,23,r|
CAS DataBase Reference 99200-09-6(CAS DataBase Reference)

Description and Uses

Nebilet was launched in Germany and the Netherlands as an antihypertensive agent. It is prepared by a five step route starting with 6-fluoro-4- oxobenzopyran-2-carboxylic acid. It is a selective β1-adrenergic receptor antagonist and is 50 times less potent at β2-receptors. Vasodialating properties occur via the nitric oxide pathway. While the L-isomer is more potent than the D-isomer, the racemic mixture is necessary for optimal activity. Upon administration, an immediate fall in blood pressure occurs, it improves both left ventricular systolic and diastolic function, and lowers peripheral blood resistance. Nebilet does not influence insulin sensitivity nor lipid profile comparible to atenolol. Doses of 50 mg of atenolol and 10 mg of Nebilet are equipotent but Nebilet has a longer duration of action due to an accumulation of the drug and increasing plasma levels of active metabolites.

Labeled Nebivolol, intended for use as an internal standard for the quantification of Nebivolol by GC- or LC-mass spectrometry.

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