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M4025335

MK-4827tosylate , 99% , 1038915-73-9

CAS NO.:1038915-73-9

Empirical Formula: C26H28N4O4S

Molecular Weight: 492.59

MDL number: MFCD28167748

Pack Size Price Stock Quantity
5mg RMB522.40 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: >142oC (dec.)
storage temp.  -20°C Freezer
solubility  Methanol (Slightly)
form  Solid
color  Off-White to Pale Yellow
InChIKey LCPFHXWLJMNKNC-XOIICWPPNA-N
SMILES S(C1C=CC(C)=CC=1)(O)(=O)=O.C(C1=CC=CC2=CN(C3C=CC([C@H]4CNCCC4)=CC=3)N=C12)(=O)N |&1:23,r|

Description and Uses

Niraparib tosylate (MK-4827 tosylate) is a highly potent and orally bioavailable PARP1 and PARP2 inhibitor with an IC50 of 3.8 and 2.1 nM, respectively; with significant activity in cancer cells with mutant BRCA-1 and BRCA-2; >330-fold selective against PARP3, V-PARP, and Tank1. Niraparib tosylate leads to inhibition of repair of DNA damage, activates apoptosis, and shows anti-tumor activity.

Niraparib is a novel oral poly(ADP-ribose)polymerase (PARP) inhibitor efficacious in BRCA-1 and -2 mutant tumors.

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

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