20-hydroxyeedysone2-acetate , ≥98% , 19536-25-5
| Pack Size | Price | Stock | Quantity |
| 5mg | RMB2200.00 | In Stock |
|
| 10mg | RMB3664.00 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 218-220 °C |
| Boiling point: | 707.3±60.0 °C(Predicted) |
| Density | 1.26±0.1 g/cm3(Predicted) |
| solubility | DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 20 mg/ml; PBS (pH 7.2): 10 mg/ml |
| form | A solid |
| pka | 13.96±0.70(Predicted) |
| color | White to off-white |
Description and Uses
2-O-Acetyl-20-hydroxyecdysone is an ecdysone steroid hormone that has been found in plants and animals. It completely inhibits the growth of the bacteria S. aureus, E. coli, and P. vulgaris, as well as the fungi C. albicans, A. alternata, and F. solani when used at a concentration of 10 μg/ml. 2-O-Acetyl-20-hydroxyecdysone (50 μM) increases aggregation of amyloid-β (1-42) (Aβ42), increases fibril formation by 60%, and decreases oligomer levels in cell-free assays. It reduces Aβ42-induced cytotoxicity of SH-SY5Y cells when used at concentrations of 5 and 10 μM.
2-O-Acetyl-20-hydroxyecdysone, an ecdysterones in insects and terrestrial plants, inhibits amyloid-β42 (Aβ42)-induced cytotoxicity. 2-O-Acetyl-20-hydroxyecdysone could decrease Aβ oligomer formation through promotion of fibrogenesis, transforming Aβ oligomers to the low-toxicity fibrils[1].
