KPT-330,Selinexor , >98% , 1393477-72-9
CAS NO.：1393477-72-9
Empirical Formula: C17H11F6N7O
Molecular Weight: 443.31
MDL number: MFCD27987944
| Pack Size | Price | Stock | Quantity |
| 5mg | RMB536.00 | In Stock |
|
| 10mg | RMB960.00 | In Stock |
|
| 50mg | RMB3120.00 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Density | 1.55±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | Soluble in DMSO (up to at least 25 mg/ml). or in Ethanol (up to at least 25 mg/ml) |
| pka | 9.74±0.43(Predicted) |
| form | solid |
| color | Off-white |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months. |
Description and Uses
Selinexor (1393477-72-9) is a potent inhibitor of the nuclear export receptor, chromosome region maintenance 1 (CRM1; Exportin-1 (XPO1)). It exhibited potent growth suppression in various T-cell acute lymphoblastic leukemia (T-ALL) cells (IC50’s = 34-203 nM)1?and pancreatic cancer cells (IC50?~ 150 nM)2. Selinexor is being investigated as a possible chemotherapeutic in treating multiple types of cancer.3-8?Currently in clinical trials.
KPT 330 is a chromosome maintenance protein 1 (CRM1) inhibitor. KPT 330 suppresses downstream effectors of B-cell activation, proliferation and migration in chronic lymphocytic leukemia cells.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H332-H302-H312 |
| Precautionary statements | P261-P271-P304+P340-P312-P264-P270-P301+P312-P330-P501-P280-P302+P352-P312-P322-P363-P501 |
