Indiplon , 98% , 325715-02-4

CAS NO.：325715-02-4

Empirical Formula: C20H16N4O2S

Molecular Weight: 376.43

MDL number:

PRODUCT Properties

• Melting point: >192oC (dec.)
• Density: 1.35±0.1 g/cm3(Predicted)
• storage temp.: Store at +4°C
• solubility: Chloroform (Slightly), Ethyl Acetate (Slightly, Heated)
• pka: -1.42±0.50(Predicted)
• form: Solid
• color: Light Yellow to Dark Yellow

Description and Uses

Indiplon is a pyrazolopyrimidine that acts as a high-affinity positive allosteric modulator of the GABA_A receptor, potentiating GABA-activated chloride currents in a dose-dependent and reversible manner. Indiplon is selective for α₁ subunits (EC₅₀ = 2.6 nM) as compared with α₂, α₃, or α₅ (EC₅₀ = 24, 60, and 77 nM). Through this action, indiplon has sedative and hypnotic effects that can improve sleep onset, maintenance, and duration.

Indiplon is a member of pyrimidines with sedative, hypnotic. Indiplon has been used in trials studying the treatment of Insomnia and Depression.