Indapamide , ≥98% , 26807-65-8

Synonym(s):
N-(4-Chloro-3-sulfamoylbenzamido)-2-methylindoline;Indapamide

CAS NO.：26807-65-8

Empirical Formula: C16H16ClN3O3S

Molecular Weight: 365.83

MDL number: MFCD00079375

EINECS: 248-012-7

PRODUCT Properties

• Melting point: 160-162°C
• Boiling point: 110.4°C (rough estimate)
• alpha: -0.8～+0.8°(D/20℃) (c=5, C2H5OH)
• Density: 1.2895 (rough estimate)
• refractive index: 1.6100 (estimate)
• storage temp.: -20°C Freezer
• solubility: Practically insoluble in water, soluble in ethanol (96 per cent).
• pka: pKa (25°) 8.8 ± 0.2
• form: Solid
• color: White to Off-White
• Water Solubility: Soluble in ethanol. Insoluble in water
• Merck: 14,4935
• BCS Class: 1
• InChIKey: NDDAHWYSQHTHNT-UHFFFAOYSA-N

Description and Uses

Indapamide is a derivative of benzolsulfonamide and its mechanism of action is analogous to that of thiazides. It is intended for lowering arterial blood pressure and as an adjuvant drug for treating edema caused by cardiac insufficiency.

Used as an antihypertensive. Diuretic.

Safety

• Symbol(GHS): GHS08
• Signal word: Warning
• Hazard statements: H361d-H362
• Precautionary statements: P202-P260-P263-P264-P270-P308+P313
• WGK Germany: 2
• RTECS: CV2451200
• HS Code: 2935904000
• Toxicity: LD50 in rats, mice, guinea pigs (mg/kg): 393-421, 410-564, 347-416 i.p.; 394-440, 577-635, 272-358 i.v.; >3000 all species orally (Kyncl)