Epacadostat(INCB-024360) , 98% , 1204669-58-8
CAS NO.：1204669-58-8
Empirical Formula: C11H13BrFN7O4S
Molecular Weight: 438.23
MDL number: MFCD26142934
| Pack Size | Price | Stock | Quantity |
| 1mg | RMB194.40 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 159 - 161°C |
| Boiling point: | 700.9±70.0 °C(Predicted) |
| Density | 2.01±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | Soluble in DMSO (up to at least 25 mg/ml) |
| form | solid |
| pka | 7.65±0.69(Predicted) |
| color | White |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
Description and Uses
Epacadostat is an inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1) with an IC50 value of 7.1 nM in HeLa cells that demonstrates little activity against the related enzymes IDO2 or tryptophan 2,3-dioxygenase (TDO). It has been shown to promote T and natural killer-cell growth, to increase IFN-γ production, and to reduce conversion to regulatory T (Treg)-like cells in a coculture system of human allogeneic lymphocytes with either dendritic cells or tumor cells. Epacadostat can also inhibit tumor growth in tumor-bearing mice in a lymphocyte-dependent manner.
Epacadostat is a potent and novel indoleamine 2,3-dioxygenase (IDO1) inhibitor with IC50 of 10 nM. It has high selectivity over IDO2 and tryptophan 2,3-dioxygenase (TDO).
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Danger |
| Hazard statements | H332-H302-H312 |
| Precautionary statements | P261-P271-P304+P340-P312-P264-P270-P301+P312-P330-P501-P280-P302+P352-P312-P322-P363-P501 |
