Home Categories Analytical Chemistry Dihydromethysticin
M2062135

Dihydromethysticin , 98% , 19902-91-1

Synonym(s):
(6S)-6-[2-(1,3-Benzodioxol-5-yl)ethyl]-5,6-dihydro-4-methoxy-2H-pyran-2-one;Dihydromethysticin

CAS NO.:19902-91-1

Empirical Formula: C15H16O5

Molecular Weight: 276.28

MDL number: MFCD00221731

Pack Size Price Stock Quantity
5mg RMB1641.60 In Stock
10mg RMB2553.60 In Stock
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Update time: 2022-07-08

PRODUCT Properties

storage temp.  2-8°C
solubility  Chloroform (Slightly), Methanol (Slightly), Pyridine (Slightly)
Boiling point: 476.1±45.0 °C(Predicted)
Density  1.28±0.1 g/cm3(Predicted)
Melting point: 117-118 °C
form  Solid
color  White to Off-White
BRN  91699
Stability: Hygroscopic
InChIKey RSIWXFIBHXYNFM-NSHDSACASA-N
LogP 1.810 (est)

Description and Uses

Dihydromethysticin is a kavalactone originally isolated from P. methysticum (kava-kava) that has diverse biological activities, including efflux transporter inhibitory, antinociceptive, and neuroprotective properties. Dihydromethysticin is a P-glycoprotein (P-gp) inhibitor that increases uptake of the P-gp substrate calcein AM by 50% in P388 mouse leukemia cancer cells overexpressing P-gp when used at a concentration of 54.6 μM. Dihydromethysticin (275 mg/kg) has analgesic activity, increasing the latency to tail withdrawal in the tail-flick assay in mice. It also decreases the infarct size in a mouse model of ischemia induced by microbipolar coagulation of the left middle cerebral artery (MCA) when administered at a dose of 10 mg/kg.

(6S)-6-[2-(1,3-Benzodioxol-5-yl)ethyl]-5,6-dihydro-4-methoxy-2H-pyran-2-one, is used in toxicity studies through in vitro analysis. This complex is found in the roots of kava plant.

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312-P330-P501
WGK Germany  3

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