Dihydromethysticin , 98% , 19902-91-1
Synonym(s):
(6S)-6-[2-(1,3-Benzodioxol-5-yl)ethyl]-5,6-dihydro-4-methoxy-2H-pyran-2-one;Dihydromethysticin
| Pack Size | Price | Stock | Quantity |
| 5mg | RMB1641.60 | In Stock |
|
| 10mg | RMB2553.60 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| storage temp. | 2-8°C |
| solubility | Chloroform (Slightly), Methanol (Slightly), Pyridine (Slightly) |
| Boiling point: | 476.1±45.0 °C(Predicted) |
| Density | 1.28±0.1 g/cm3(Predicted) |
| Melting point: | 117-118 °C |
| form | Solid |
| color | White to Off-White |
| BRN | 91699 |
| Stability: | Hygroscopic |
| InChIKey | RSIWXFIBHXYNFM-NSHDSACASA-N |
| LogP | 1.810 (est) |
Description and Uses
Dihydromethysticin is a kavalactone originally isolated from P. methysticum (kava-kava) that has diverse biological activities, including efflux transporter inhibitory, antinociceptive, and neuroprotective properties. Dihydromethysticin is a P-glycoprotein (P-gp) inhibitor that increases uptake of the P-gp substrate calcein AM by 50% in P388 mouse leukemia cancer cells overexpressing P-gp when used at a concentration of 54.6 μM. Dihydromethysticin (275 mg/kg) has analgesic activity, increasing the latency to tail withdrawal in the tail-flick assay in mice. It also decreases the infarct size in a mouse model of ischemia induced by microbipolar coagulation of the left middle cerebral artery (MCA) when administered at a dose of 10 mg/kg.
(6S)-6-[2-(1,3-Benzodioxol-5-yl)ethyl]-5,6-dihydro-4-methoxy-2H-pyran-2-one, is used in toxicity studies through in vitro analysis. This complex is found in the roots of kava plant.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P264-P270-P301+P312-P330-P501 |
| WGK Germany | 3 |
