14-Deoxy-11,12-didehydroandrographolide? , >98% , 42895-58-9

Synonym(s):
ent-(3β,11E)-3,19-Dihydroxy-8(17),11,13-labdatrien-16,15-olide;3-[(1E)-2-[(1R,4aS,5R,6R,8aR)-Decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethenyl]- 2(5H)-furanone

CAS NO.：42895-58-9

Empirical Formula: C20H28O4

Molecular Weight: 332.43

MDL number: MFCD07778081

EINECS: 226-852-5

PRODUCT Properties

• Melting point: 204-205℃
• Boiling point: 519.6±50.0 °C(Predicted)
• Density: 1.17
• storage temp.: Store at -20°C
• solubility: DMF: 10 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 2 mg/ml
• pka: 14.80±0.70(Predicted)
• form: Solid
• color: White to off-white

Description and Uses

14-deoxy-11,12-didehydro Andrographolide is an analog of the natural diterpenoid andrographolide that can be isolated from A. paniculata. It retains the anti-inflammatory, antiallergenic, immuno-stimulatory, antiviral, antioxidant, hepatoprotective, and cardiovascular activities of andrographolide without producing cytotoxicity in KB cells (ED₅₀ >20 μg/ml) that can occur with andrographolide 6.5 μg/ml.

14-Deoxy-11,12-didehydroandrographolide is the derivative of Andrographolide(A637475) is a labdane diterpenoid (2). Andrographolide is the main bioactive component isolated from the medicinal plant Andrographis paniculata (2). Andrographolide showed significant antihepatotoxic action in P. berghei K173-induced hepatic damage in M. natalensis(1). Andrographolide inhibits tumor necrosis factor-α (TNF-α)-induced intercellular adhesion mol.-1 (ICAM-1) expression and adhesion of HL-60 cells onto human umbilical vein endothelial cells (HUVEC), which are associated with inflammatory diseases (2). These findings suggest that Andrographolide may have potential as a cardiovascular-protective agent.

Safety

• WGK Germany: 3