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M1533141

Clavulanateacid , ≥98% , 58001-44-8

CAS NO.:58001-44-8

Empirical Formula: C8H9NO5

Molecular Weight: 199.16

MDL number: MFCD00867004

EINECS: 261-069-2

Pack Size Price Stock Quantity
5mg RMB4000.00 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Boiling point: 545.8±50.0 °C(Predicted)
Density  1.65±0.1 g/cm3(Predicted)
storage temp.  4°C, protect from light, stored under nitrogen
solubility  H2O : 50 mg/mL (251.05 mM; Need ultrasonic)
form  Solid
pka 3.68±0.20(Predicted)
color  Off-white to light yellow

Description and Uses

Clavulanic acid is a mold product with only weak intrinsic antibacterial activity, but it is an excellent irreversible inhibitor of most β-lactamases. It is believed to acylate the active site serine by mimicking the normal substrate. Hydrolysis occurs with some β-lactamases, but in many cases, subsequent reactions occur that inhibit the enzyme irreversibly. This leads to its classification as a mechanism-based inhibitor (or so-called suicide substrate). The precise chemistry is not well understood, but when clavulanic acid is added to ampicillin and amoxicillin preparations, the potency against β-lactamase–producing strains is markedly enhanced.

beta-lactamase inhibitor

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

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