Clavulanateacid , ≥98％ , 58001-44-8
CAS NO.：58001-44-8
Empirical Formula: C8H9NO5
Molecular Weight: 199.16
MDL number: MFCD00867004
EINECS: 261-069-2
| Pack Size | Price | Stock | Quantity |
| 5mg | RMB4000.00 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Boiling point: | 545.8±50.0 °C(Predicted) |
| Density | 1.65±0.1 g/cm3(Predicted) |
| storage temp. | 4°C, protect from light, stored under nitrogen |
| solubility | H2O : 50 mg/mL (251.05 mM; Need ultrasonic) |
| form | Solid |
| pka | 3.68±0.20(Predicted) |
| color | Off-white to light yellow |
Description and Uses
Clavulanic acid is a mold product with only weak intrinsic antibacterial activity, but it is an excellent irreversible inhibitor of most β-lactamases. It is believed to acylate the active site serine by mimicking the normal substrate. Hydrolysis occurs with some β-lactamases, but in many cases, subsequent reactions occur that inhibit the enzyme irreversibly. This leads to its classification as a mechanism-based inhibitor (or so-called suicide substrate). The precise chemistry is not well understood, but when clavulanic acid is added to ampicillin and amoxicillin preparations, the potency against β-lactamase–producing strains is markedly enhanced.
beta-lactamase inhibitor
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
