FludrocortisoneAcetateSolution , 1.00mg/ml , 514-36-3

Synonym(s):
9α-Fluoro-11β,17α,21-trihydroxy-4-pregnene-3,20-dione acetate;9-Fluorocortisol acetate;9-Fluorohydrocortisone acetate

CAS NO.：514-36-3

Empirical Formula: C23H31FO6

Molecular Weight: 422.49

MDL number: MFCD00864160

EINECS: 208-180-4

PRODUCT Properties

• Melting point: 233-234°C
• alpha: D23 +123° (c = 0.64 in chloroform)
• Boiling point: 575.1±50.0 °C(Predicted)
• Density: 1.0953 (rough estimate)
• refractive index: 1.5980 (estimate)
• storage temp.: 2-8°C
• solubility: Practically insoluble in water, sparingly soluble in anhydrous ethanol.
• pka: 12.06±0.70(Predicted)
• form: Solid
• color: White to Off-White
• Water Solubility: 54mg/L(25 ºC)
• InChIKey: UUHYILPJUKGJDI-XYNXPQAZSA-N
• SMILES: F[C@]12[C@H](C[C@@]3([C@@](O)(C(=O)COC(=O)C)CC[C@@]3([H])[C@]1([H])CCC1=CC(=O)CC[C@]21C)C)O |&1:1,2,4,5,16,18,28,r|

Description and Uses

Fludrocortisone acetate is the acetate form of the synthetic corticosteroid fludrocortisone, which is a mineralocorticoid receptor agonist. Fludrocortisone acetate (0.1-5 μg/animal) promotes sodium retention in rats in a dose-dependent manner with 37% of sodium excreted compared with control when used at a dose of 5 μg/animal. Formulations containing fludrocortisone acetate have been used in the treatment of Addison’s disease.

Safety

• Symbol(GHS): GHS07,GHS08
• Signal word: Warning
• Hazard statements: H302-H361
• Precautionary statements: P280-P301+P312+P330
• Hazard Codes: Xn
• Risk Statements: 63
• Safety Statements: 22-26-36
• WGK Germany: 3
• RTECS: TU5050000
• HS Code: 2937220000
• Toxicity: LD50 oral in rat: > 1gm/kg