M1522641
FludrocortisoneAcetateSolution , 1.00mg/ml , 514-36-3
Synonym(s):
9α-Fluoro-11β,17α,21-trihydroxy-4-pregnene-3,20-dione acetate;9-Fluorocortisol acetate;9-Fluorohydrocortisone acetate
CAS NO.:514-36-3
Empirical Formula: C23H31FO6
Molecular Weight: 422.49
MDL number: MFCD00864160
EINECS: 208-180-4
Pack Size | Price | Stock | Quantity |
1ml | RMB668.00 | In Stock |
|
others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
Melting point: | 233-234°C |
Boiling point: | 575.1±50.0 °C(Predicted) |
alpha | D23 +123° (c = 0.64 in chloroform) |
Density | 1.0953 (rough estimate) |
refractive index | 1.5980 (estimate) |
storage temp. | 2-8°C |
solubility | Practically insoluble in water, sparingly soluble in anhydrous ethanol. |
pka | 12.06±0.70(Predicted) |
form | Solid |
color | White to Off-White |
Water Solubility | 54mg/L(25 ºC) |
InChIKey | UUHYILPJUKGJDI-XYNXPQAZSA-N |
SMILES | F[C@]12[C@H](C[C@@]3([C@@](O)(C(=O)COC(=O)C)CC[C@@]3([H])[C@]1([H])CCC1=CC(=O)CC[C@]21C)C)O |&1:1,2,4,5,16,18,28,r| |
CAS DataBase Reference | 514-36-3(CAS DataBase Reference) |
EPA Substance Registry System | Fluorocortisone acetate (514-36-3) |
Description and Uses
Fludrocortisone acetate is the acetate form of the synthetic corticosteroid fludrocortisone, which is a mineralocorticoid receptor agonist. Fludrocortisone acetate (0.1-5 μg/animal) promotes sodium retention in rats in a dose-dependent manner with 37% of sodium excreted compared with control when used at a dose of 5 μg/animal. Formulations containing fludrocortisone acetate have been used in the treatment of Addison’s disease.
Safety
Symbol(GHS) | GHS07,GHS08 |
Signal word | Warning |
Hazard statements | H302-H361 |
Precautionary statements | P280-P301+P312+P330 |
Hazard Codes | Xn |
Risk Statements | 63 |
Safety Statements | 22-26-36 |
WGK Germany | 3 |
RTECS | TU5050000 |
HS Code | 2937220000 |
Toxicity | LD50 oral in rat: > 1gm/kg |