Calcipotriolmonohydrate? , ≥99% , 147657-22-5

CAS NO.：147657-22-5

Empirical Formula: C27H40O3.H2O

Molecular Weight: 430.625

MDL number: MFCD10567086

EINECS: 689-035-6

PRODUCT Properties

• storage temp.: 4°C, protect from light, stored under nitrogen,unstable in solution, ready to use.
• solubility: Practically insoluble in water, freely soluble in ethanol (96 per cent), slightly soluble in methylene chloride.
• form: Powder
• color: White to off-white
• Stability: Hygroscopic, Light sensitive
• InChIKey: XBKHACNRWFKJNC-IZXATKCONA-N
• SMILES: C[C@]12CCC/C(=C\C=C3\C[C@@H](O)C[C@H](O)C\3=C)/[C@]1([H])CC[C@]2([H])[C@H](C)/C=C/[C@H](C1CC1)O.O |&1:1,10,13,17,21,23,27,r|

Description and Uses

Calcipotriol (hydrate) is a low-calcemic vitamin D receptor (VDR) agonist. Calcipotriol (hydrate) is about 200 times less potent in its effects on calcium metabolism than vitamin D (1,25[OH]D₃). Binding of calcipotriol (hydrate) to the VDR increases AP-1, a transcription factor important for keratinocyte differentiation, and reduces expression of JunB protein, a transcriptional activator in the inflammatory response. Calcipotriol (hydrate) also induces expression of thymic stromal lymphopoietin, which triggers T-cell differentiation in keratinocytes.

Calcipotriol monohydrate is a synthetic vitamin D3 analog with high affinity for the vitamin D receptor. It is used alone or in combination with betamethasone dipropionate for the treatment of psoriasis.

Safety

• Symbol(GHS): GHS06
• Signal word: Danger
• Hazard statements: H310
• Precautionary statements: P262-P264-P270-P280-P302+P350-P310-P322-P361-P363-P405-P501