Home Categories Analytical Chemistry Calcipotriolmonohydrate?
M0916535

Calcipotriolmonohydrate? , ≥99% , 147657-22-5

CAS NO.:147657-22-5

Empirical Formula: C27H40O3.H2O

Molecular Weight: 430.625

MDL number: MFCD10567086

EINECS: 689-035-6

Pack Size Price Stock Quantity
5mg RMB738.40 In Stock
10mg RMB1167.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

storage temp.  4°C, protect from light, stored under nitrogen,unstable in solution, ready to use.
solubility  Practically insoluble in water, freely soluble in ethanol (96 per cent), slightly soluble in methylene chloride.
form  Powder
color  White to off-white
Stability: Hygroscopic, Light sensitive
InChIKey XBKHACNRWFKJNC-IZXATKCONA-N
SMILES C[C@]12CCC/C(=C\C=C3\C[C@@H](O)C[C@H](O)C\3=C)/[C@]1([H])CC[C@]2([H])[C@H](C)/C=C/[C@H](C1CC1)O.O |&1:1,10,13,17,21,23,27,r|

Description and Uses

Calcipotriol (hydrate) is a low-calcemic vitamin D receptor (VDR) agonist. Calcipotriol (hydrate) is about 200 times less potent in its effects on calcium metabolism than vitamin D (1,25[OH]D3). Binding of calcipotriol (hydrate) to the VDR increases AP-1, a transcription factor important for keratinocyte differentiation, and reduces expression of JunB protein, a transcriptional activator in the inflammatory response. Calcipotriol (hydrate) also induces expression of thymic stromal lymphopoietin, which triggers T-cell differentiation in keratinocytes.

Calcipotriol monohydrate is a synthetic vitamin D3 analog with high affinity for the vitamin D receptor. It is used alone or in combination with betamethasone dipropionate for the treatment of psoriasis.

Safety

Symbol(GHS) 
GHS06
Signal word  Danger
Hazard statements  H310
Precautionary statements  P262-P264-P270-P280-P302+P350-P310-P322-P361-P363-P405-P501

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