Corosolicacid , Analysis of control products, 98% , 4547-24-4
Synonym(s):
Corosolic acid;2α-Hydroxyursolic acid;Glucosol;Colosolic acid;(2α,3β)-2,3-Dihydroxyurs-12-en-28-oic acid
CAS NO.：4547-24-4
Empirical Formula: C30H48O4
Molecular Weight: 472.7
MDL number: MFCD06794973
EINECS: 610-253-4
| Pack Size | Price | Stock | Quantity |
| 25mg | RMB684.00 | In Stock |
|
| 100mg | RMB1968.00 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 243～245℃ |
| Boiling point: | 573.3±50.0 °C(Predicted) |
| Density | 1.14±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | methanol: soluble1mg/mL, clear, colorless |
| form | Solid |
| pka | 4.67±0.70(Predicted) |
| color | White |
| LogP | 7.113 (est) |
Description and Uses
Corosolic acid is a triterpenoid that has been found in L. speciosa leaves and has diverse biological activities, including anticancer, anti-inflammatory, antidiabetic, antihypertensive, antihyperlipidemic, and antioxidant properties. It is cytotoxic to HepG2, A549, SNU-C4, HeLa S3, and K562 cells (EC50s = 4.8, 5, 0.4, 1, and 4.3 μg/ml, respectively). Corosolic acid inhibits ear edema in mice induced by phorbol 12-myristate 13-acetate (TPA; ) with an ID50 value of 0.09 mg/ear. It reduces blood glucose levels in an insulin tolerance test in a KKAy mouse model of type 2 diabetes when administered at doses of 2 and 10 mg/kg. Corosolic acid (0.072% in the diet) reduces systolic blood pressure and serum levels of free fatty acids, the oxidative stress markers thiobarbituric acid-reactive substances (TBARS) and 8-hydroxy-2’-deoxyguanosine (8-OHdG), and the myeloperoxidase markers 3-nitrotyrosine and 3-chlorotyrosine in an SHR/NDmcr-cp (cp/cp) rat model of metabolic syndrome.
(2α,3β)-2,3-Dihydroxy-urs-12-en-28-oic Acid influences inflammatory gene expression regarding inflammatory bowel disease. In addition, its extracted from the plants Gentiana farreri and shows anti-tumor activity
Safety
| WGK Germany | 3 |
| HS Code | 2918195000 |
