Bisdethiobis(methylthio)gliotoxin , 95% , 74149-38-5

CAS NO.：74149-38-5

Empirical Formula: C15H20N2O4S2

Molecular Weight: 356.46

MDL number: MFCD00133146

PRODUCT Properties

• Boiling point: 669.6±55.0 °C(Predicted)
• Density: 1.49±0.1 g/cm3(Predicted)
• storage temp.: −20°C
• solubility: Chloroform (Slightly), Methanol (Slightly)
• form: White solid.
• pka: 12.69±0.60(Predicted)
• color: Off-White to Yellow

Description and Uses

Bis(methylthio)gliotoxin is a fungal metabolite originally isolated from G. deliquescens that has diverse biological activities. It inhibits PAF- and collagen-induced platelet aggregation in rabbit platelet-rich plasma (IC₅₀s = 8.4 and 84.2 μM, respectively) but has no effect on arachidonic acid- or ADP-induced platelet aggregation (IC₅₀s = >400 μM). Bis(methylthio)gliotoxin inhibits growth of HCT116 colon cancer cells (IC₅₀ = 23.56 μM). It inhibits PAF-induced bronchoconstriction in guinea pigs when administered at a dose of 0.1 mg/kg and is less toxic to mice (LD₅₀ = >500 mg/kg) than gliotoxin . Bis(methylthio)gliotoxin has been used as a serum biomarker in patients infected with invasive aspergillosis.

Bis(methylthio)gliotoxin (FR-49175) is an antiphagocytic metabolite.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302+H312+H332
• Precautionary statements: P261-P264b-P270-P271-P280-P302+P352-P304+P340-P312-P330-P363-P403-P501c
• Hazard Codes: Xn
• Risk Statements: 20/21/22
• Safety Statements: 36
• RIDADR: 1544
• HazardClass: 6.1(b)
• PackingGroup: III