BarnidipineHCl , ≥99% , 104757-53-1
| Pack Size | Price | Stock | Quantity |
| 10mg | RMB624.80 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 223-226°C |
| alpha | D20 +116.4° (c = 1 in methanol) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | insoluble in H2O; insoluble in EtOH; ≥16.3 mg/mL in DMSO with gentle warming |
| form | A crystalline solid |
| color | Light yellow to yellow |
| CAS DataBase Reference | 104757-53-1(CAS DataBase Reference) |
Description and Uses
Barnidipine hydrochloride, chemically known as (3S)-1-benzyl-3-pyrrolidinylmethyl-(4S)-2,6-dimethyl-4-(m-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride, is a new long-acting dihydropyridine calcium antagonist developed and marketed by Yamanouchi Pharmaceutical (now Astellas Pharma). This medication effectively lowers blood pressure without impacting heart rate by specifically targeting calcium channels responsible for transmembrane potential. By inhibiting calcium influx into cells, it selectively relaxes smooth muscle in peripheral and coronary blood vessels.
Barnidipine hydrochloride is a vasodilating dihydropyridine calcium antagonist useful in the treatment of primary hypertension and renal hypertension. In experimental animals, its hypotensive effect was more potent and longer acting than nicardipine, nifedipine and nitrendipine.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H317-H319 |
| Precautionary statements | P280-P305+P351+P338 |
| Toxicity | LD50 orally in male, female rats: 105, 113 mg/kg (Satoh) |
