concanamycinA , 95% , 80890-47-7

Synonym(s):
Concanamycin A;Folimycin;Folimycin, Streptomyces sp. - CAS 80890-47-7 - Calbiochem

CAS NO.：80890-47-7

Empirical Formula: C46H75NO14

Molecular Weight: 866.09

MDL number: MFCD00210037

EINECS: 620-709-4

PRODUCT Properties

• Melting point: 179-180℃ (dichloromethane ethanol )
• Boiling point: 966.4±65.0 °C(Predicted)
• Density: 1.20±0.1 g/cm3(Predicted)
• storage temp.: −20°C
• solubility: Soluble in DMSO
• form: Lyophilized solid
• pka: 12.46±0.70(Predicted)
• color: White
• BRN: 3560277
• Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.

Description and Uses

Concanamycin A (80890-47-7) is a potent and specific inhibitor of the vacuolar (V-type) H+-ATPase which can induce apoptotic cell death in various cell lines.1,2?Inhibits cell surface expression of virus envelope glycoproteins.3?Dramatically increases the rate of extracellular vesicle release from a variety of cell types.4?Inhibits autophagy by blocking lysosomal acidification.5

Concanamycin A has been used:

• as a lysosomal inhibitor in young and old fibroblasts
• as a vacuolar-type H⁺-ATPase inhibitor in presynaptic vesicles
• as a lysosomal acidification blocker in HepG2 hepatocytes cells

Safety

• Symbol(GHS): GHS06
• Signal word: Danger
• Hazard statements: H300+H310+H330-H319
• Precautionary statements: P262-P280-P301+P310+P330-P302+P352+P310-P304+P340+P310-P305+P351+P338
• Hazard Codes: T+
• Risk Statements: 26/27/28-36
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 3462 6.1/PG 2
• WGK Germany: 3
• RTECS: CB9732000
• F: 10-21
• HazardClass: 6.1(b)
• PackingGroup: III
• HS Code: 2941900000