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LN9813546

concanamycinA , 95% , 80890-47-7

Synonym(s):
Concanamycin A;Folimycin;Folimycin, Streptomyces sp. - CAS 80890-47-7 - Calbiochem

CAS NO.:80890-47-7

Empirical Formula: C46H75NO14

Molecular Weight: 866.09

MDL number: MFCD00210037

EINECS: 620-709-4

Pack Size Price Stock Quantity
100ug RMB5734.40 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 179-180℃ (dichloromethane ethanol )
Boiling point: 966.4±65.0 °C(Predicted)
Density  1.20±0.1 g/cm3(Predicted)
storage temp.  −20°C
solubility  Soluble in DMSO
form  Lyophilized solid
pka 12.46±0.70(Predicted)
color  White
BRN  3560277
Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.

Description and Uses

Concanamycin A (80890-47-7) is a potent and specific inhibitor of the vacuolar (V-type) H+-ATPase which can induce apoptotic cell death in various cell lines.1,2?Inhibits cell surface expression of virus envelope glycoproteins.3?Dramatically increases the rate of extracellular vesicle release from a variety of cell types.4?Inhibits autophagy by blocking lysosomal acidification.5

Concanamycin A has been used:

  • as a lysosomal inhibitor in young and old fibroblasts
  • as a vacuolar-type H+-ATPase inhibitor in presynaptic vesicles
  • as a lysosomal acidification blocker in HepG2 hepatocytes cells

Safety

Symbol(GHS) 
GHS06
Signal word  Danger
Hazard statements  H300+H310+H330-H319
Precautionary statements  P262-P280-P301+P310+P330-P302+P352+P310-P304+P340+P310-P305+P351+P338
Hazard Codes  T+
Risk Statements  26/27/28-36
Safety Statements  26-36/37/39-45
RIDADR  UN 3462 6.1/PG 2
WGK Germany  3
RTECS  CB9732000
10-21
HazardClass  6.1(b)
PackingGroup  III
HS Code  2941900000

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