LN9813446
ConcanamycinA , 80% , 80890-47-7
Synonym(s):
Concanamycin A;Folimycin;Folimycin, Streptomyces sp. - CAS 80890-47-7 - Calbiochem
CAS NO.:80890-47-7
Empirical Formula: C46H75NO14
Molecular Weight: 866.09
MDL number: MFCD00210037
EINECS: 620-709-4
Pack Size | Price | Stock | Quantity |
100ug | RMB1791.20 | In Stock |
|
others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
Melting point: | 179-180℃ (dichloromethane ethanol ) |
Boiling point: | 966.4±65.0 °C(Predicted) |
Density | 1.20±0.1 g/cm3(Predicted) |
storage temp. | −20°C |
solubility | Soluble in DMSO |
form | Lyophilized solid |
pka | 12.46±0.70(Predicted) |
color | White |
BRN | 3560277 |
Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month. |
Description and Uses
Concanamycin A (80890-47-7) is a potent and specific inhibitor of the vacuolar (V-type) H+-ATPase which can induce apoptotic cell death in various cell lines.1,2?Inhibits cell surface expression of virus envelope glycoproteins.3?Dramatically increases the rate of extracellular vesicle release from a variety of cell types.4?Inhibits autophagy by blocking lysosomal acidification.5
Concanamycin A has been used:
- as a lysosomal inhibitor in young and old fibroblasts
- as a vacuolar-type H+-ATPase inhibitor in presynaptic vesicles
- as a lysosomal acidification blocker in HepG2 hepatocytes cells
Safety
Symbol(GHS) | GHS06 |
Signal word | Danger |
Hazard statements | H300+H310+H330-H319 |
Precautionary statements | P262-P280-P301+P310+P330-P302+P352+P310-P304+P340+P310-P305+P351+P338 |
Hazard Codes | T+ |
Risk Statements | 26/27/28-36 |
Safety Statements | 26-36/37/39-45 |
RIDADR | UN 3462 6.1/PG 2 |
WGK Germany | 3 |
RTECS | CB9732000 |
F | 10-21 |
HazardClass | 6.1(b) |
PackingGroup | III |
HS Code | 2941900000 |