Celecoxib carboxylic acid acyl-b-D-glucuronide , ≥95% , 264236-79-5

CAS NO.：264236-79-5

Empirical Formula: C23H20F3N3O10S

Molecular Weight: 587.48

MDL number:

PRODUCT Properties

• Melting point: >147°C (dec.)
• Boiling point: 836.7±75.0 °C(Predicted)
• Density: 1.77±0.1 g/cm3(Predicted)
• storage temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• solubility: Methanol (Slightly, Heated)
• form: Solid
• pka: 2.66±0.70(Predicted)
• color: Off-White to Pale Yellow
• Stability: Hygroscopic

Description and Uses

Celecoxib carboxylic acid acyl-β-D-glucuronide is a phase II metabolite of celecoxib . Celecoxib is an anti-inflammatory compound from the diaryl heterocycle class that selectively inhibits cyclooxygenase-2 (COX-2; IC₅₀s = 22.9 and 0.05 μM for COX-1 and COX-2, respectively). Celecoxib carboxylic acid acyl-β-D-glucuronide is a minor metabolite, accounting for 2% of the administered dose in human urine and rat bile.

Celecoxib Carboxylic Acid Acyl-β-D-glucuronide is a glucuronide metabolite of Celecoxib (C251000), a Cox-2 inhibitor.