50%solutioninethylacetate , 68957-94-8

Synonym(s):
1-Propanephosphonic anhydride solution;2,4,6-Tripropyl-1,3,5,2,4,6-trioxatriphosphorinane-2,4,6-trioxide solution;PPACA;T3P

Update time: 2022-07-08

Boiling point:	65 °C
Density	1.069 g/mL at 25 °C
vapor pressure	0Pa at 25℃
refractive index	n20/D 1.418
Flash point:	25 °F
storage temp.	Flammables area
solubility	Miscible with dioxane, terahydrofuran, dimethyl formamide, polar and aprotic organic solvents.
form	Solution
color	Clear yellow to brownish
Water Solubility	9.6g/L at 25℃
Sensitive	Moisture Sensitive
BRN	5079255
Exposure limits	ACGIH: TWA 20 ppm (Skin) OSHA: TWA 40 ppm(70 mg/m3) NIOSH: IDLH 137 ppm(25 mg/m3); TWA 20 ppm(34 mg/m3)
Stability:	Moisture Sensitive
LogP	0 at 25℃

Propylphosphonic anhydride may be used in the following studies:

As coupling agent for the synthesis of bispyridine-based ligands, which are used as bridging linkers in multinuclear platinum anticancer drugs.
Microwave-assissted Fischer indolization of arylhydrazines.
As acid activating agent for the direct synthesis of acid azides from carboxylic acids.
One-pot synthesis of coumarins.
Microwave-mediated synthesis of carbocyclic and heterocyclic fused quinolones.
One-pot synthesis of 1,2,4-oxadiazoles, 1,3,4-oxadiazoles, and 1,3,4-thiadiazoles from carboxylic acids.
Activation of the carboxyl group for hydroxyamidation and peptide coupling and in the one-pot conversion of carboxylic acids into hydroxamic acids.