LN7174152
JNJ-?10198409 , 98.51% , 627518-40-5
Synonym(s):
3-Fluoro-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamine;3-Fluoro-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamine, JNJ-10198409;N-(3-fluorophenyl)-2,4-dihydro-6,7-dimethoxy-Indeno[1,2-c]pyrazol-3-amine;PDGFR Tyrosine Kinase Inhibitor IV - CAS 627518-40-5 - Calbiochem;RWJ 540973
CAS NO.：627518-40-5
Empirical Formula: C18H16FN3O2
Molecular Weight: 325.34
MDL number: MFCD11045292
| Pack Size | Price | Stock | Quantity |
| 5mg | RMB3181.60 | In Stock |
|
| 1mL*10mM(inDMSO) | RMB3189.60 | In Stock |
|
| 10mg | RMB4773.60 | In Stock |
|
| 25mg | RMB8592.00 | In Stock |
|
| 50mg | RMB12893.60 | In Stock |
|
| 100mg | RMB19341.60 | In Stock |
|
| 200mg | RMB29012.80 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 171-173.5 °C |
| Boiling point: | 528.8±50.0 °C(Predicted) |
| Density | 1.366±0.06 g/cm3(Predicted) |
| storage temp. | −20°C |
| solubility | DMSO: >10mg/mL |
| form | solid |
| pka | 14.01±0.20(Predicted) |
| color | off-white |
Description and Uses
JNJ-10198409 is a relatively selective, orally active, and ATP competitive PDGF-RTK (platelet-derived growth factor receptor tyrosine kinase) inhibitor (IC50=2 nM). It is a dual-mechanism, antiangiogenic, and tumor cell antiproliferative agent. JNJ-10198409 has good activity against PDGFR-β kinase (IC50=4.2 nM) and PDGFR-α kinase (IC50=45 nM)[1][2].
Safety
| WGK Germany | 3 |
