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LN7167846

Methylprednisoloneaceponate , 95+% , 86401-95-8

CAS NO.:86401-95-8

Empirical Formula: C27H36O7

Molecular Weight: 472.57

MDL number: MFCD00866150

EINECS: 608-705-0

Pack Size Price Stock Quantity
250mg RMB484.00 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 105 - 108°C
Boiling point: 595.8±50.0 °C(Predicted)
Density  1.23±0.1 g/cm3(Predicted)
storage temp.  Sealed in dry,Room Temperature
solubility  Chloroform (Slightly), Dioxane (Slightly), DMSO (Slightly), Ethyl Acetate(Slightly)
form  Solid
pka 14.05±0.70(Predicted)
color  White to Off-White
InChIKey DALKLAYLIPSCQL-TXWHWSFMNA-N
SMILES O(C(CC)=O)[C@]1(C(COC(C)=O)=O)CC[C@H]2[C@@H]3C[C@H](C)C4=CC(C=C[C@]4(C)[C@H]3[C@H](C[C@]12C)O)=O |&1:5,15,16,18,25,27,28,30,r|

Description and Uses

Methylprednisolone aceponate (MPA) is a new potent topical corticosteroid. Chemically, it is a corticosteroid diester that penetrates the skin rapidly. It is rapidly metabolised and then conjugated, so although potent, it does not appear to cause serious local or systemic side effects. Clinical trials have shown that once daily use is sufficient to control most eczematous conditions and is also appropriate and effective in atopic dermatitis. MPA is effective in the treatment of facial and scalp eczema and sunburn and has shown promising results in the treatment of psoriasis. MPA is also suitable for use in children and infants. MPA is available in a wide range of formulations (0.1%) including creams, ointments, fat ointments, lotions and solutions depending on the patient's individual condition.

Methylprednisolone aceponate used in treatment of seborrhoeic dermatitis includes topical treatments such as corticosteroids, antifungals, metronidazole and pimecrolimus.

Safety

Symbol(GHS) 
GHS08
Signal word  Warning
Hazard statements  H361
Precautionary statements  P201-P202-P281-P308+P313-P405-P501

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