Indomethacinheptylester(solutioninacetate) , ≥98% , 282728-47-6

CAS NO.：282728-47-6

Empirical Formula: C26H30ClNO4

Molecular Weight: 455.97

MDL number: MFCD03412025

PRODUCT Properties

• Flash point: -16 °C
• storage temp.: −20°C
• solubility: ≤17mg/ml in ethanol;17mg/ml in DMSO;17mg/ml in dimethyl formamide
• form: methyl acetate solution

Description and Uses

Indomethacin is a potent but non-selective inhibitor of both COX-1 and COX-2 in sheep and humans. Structurally, indomethacin is a substituted indole acetic acid, wherein the carboxylate can be derivatized as an ester or amide. These derivatives show enhanced selectivity for the COX-2 isoform. For example, the IC₅₀ for indomethacin heptyl ester for the inhibition of human recombinant COX-2 is 0.04 μM, making it more than 1,700 times more potent as an inhibitor of COX-2 than COX-1. While indomethacin itself has an IC₅₀ of 0.05 μM for the inhibition of COX-2, it also inhibits COX-1 with a corresponding IC₅₀ of 0.67 μM.

Safety

• Symbol(GHS): GHS02,GHS07
• Signal word: Danger
• Hazard statements: H225-H319-H336
• Precautionary statements: P210-P240-P241-P242-P243-P261-P264-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P312-P337+P313-P370+P378-P403+P233-P403+P235-P405-P501
• Hazard Codes: F,Xi
• Risk Statements: 11-36-66-67
• Safety Statements: 16-26-29-33-36
• RIDADR: UN 1231 3/PG 2
• WGK Germany: 1
• RTECS: AI9100000