Ziconotideacetate , ≥95% , 107452-89-1
Synonym(s):
SNX-111;Ziconotide
CAS NO.:107452-89-1
Empirical Formula: C102H172N36O32S7
Molecular Weight: 2639.13
MDL number: MFCD00145036
Pack Size | Price | Stock | Quantity |
5mg | RMB2000.00 | In Stock |
|
25mg | RMB4400.00 | In Stock |
|
50mg | RMB6560.00 | In Stock |
|
others | Enquire |
PRODUCT Properties
Density | 1.60±0.1 g/cm3(Predicted) |
storage temp. | -20°C |
solubility | DMSO (Slightly, Sonicated), Methanol (Slightly) |
form | Solid |
color | White to Off-White |
InChIKey | BPKIMPVREBSLAJ-QTBYCLKRSA-N |
Description and Uses
ω-conotoxin MVIIA, also knwn as Ziconotide acetate, is a peptide consisting of 25 amino acid. It is a disulfide-bridged polypeptide from the venom of the sea snail Conusmagus that binds to neuronal N-type calcium channels. It forms a compact folded structure, presenting a loop between Cys8 and Cys15 that contains a set of residues critical for its binding. Both ω-conotoxins GVIA and MVIIA could bind to neuronal N-type calcium channels. ω-conotoxin GVIA is rich in hydroxyl groups while ω-conotoxin MVIIA contains a large number of positively charged side chains[1-2].
Ziconotide acetate (ω-Conotoxin MVIIA), the peptide toxin of the Conus magus (cone snail) is a selective antagonist of N-type voltage sensitive calcium channels (VSCC). As a most well-known identified conotoxin so far, it has been used as a effective drug to treat intractable chronic pain in cancer and ADIS patients[2]. Blocks neurotransmitter release by preventing depolarization-induced calcium influx. Used as a ligand for binding studies of voltage sensitive calcium channels. Analgesic; neuroprotective.
Safety
Symbol(GHS) | GHS06 |
Signal word | Danger |
Hazard statements | H301+H331 |
Precautionary statements | P261-P304+P340+P312-P403+P233 |
RIDADR | 3172 |
WGK Germany | 3 |
HazardClass | 6.1(b) |
PackingGroup | III |
Hazardous Substances Data | 107452-89-1(Hazardous Substances Data) |