Ziconotideacetate , ≥95% , 107452-89-1

Synonym(s):
SNX-111;Ziconotide

CAS NO.：107452-89-1

Empirical Formula: C102H172N36O32S7

Molecular Weight: 2639.13

MDL number: MFCD00145036

PRODUCT Properties

• Density: 1.60±0.1 g/cm3(Predicted)
• storage temp.: -20°C
• solubility: DMSO (Slightly, Sonicated), Methanol (Slightly)
• form: Solid
• color: White to Off-White
• InChIKey: BPKIMPVREBSLAJ-QTBYCLKRSA-N

Description and Uses

ω-conotoxin MVIIA, also knwn as Ziconotide acetate, is a peptide consisting of 25 amino acid.  It is a disulfide-bridged polypeptide from the venom of the sea snail Conusmagus that binds to neuronal N-type calcium channels. It forms a compact folded structure, presenting a loop between Cys8 and Cys15 that contains a set of residues critical for its binding. Both ω-conotoxins GVIA and MVIIA could bind to neuronal N-type calcium channels. ω-conotoxin GVIA is rich in hydroxyl groups while ω-conotoxin MVIIA contains a large number of positively charged side chains[1-2].

Ziconotide acetate (ω-Conotoxin MVIIA), the peptide toxin of the Conus magus (cone snail) is a selective antagonist of N-type voltage sensitive calcium channels (VSCC). As a most well-known identified conotoxin so far, it has been used as a effective drug to treat intractable chronic pain in cancer and ADIS patients[2]. Blocks neurotransmitter release by preventing depolarization-induced calcium influx. Used as a ligand for binding studies of voltage sensitive calcium channels. Analgesic; neuroprotective.

Safety

• Symbol(GHS): GHS06
• Signal word: Danger
• Hazard statements: H301+H331
• Precautionary statements: P261-P304+P340+P312-P403+P233
• RIDADR: 3172
• WGK Germany: 3
• HazardClass: 6.1(b)
• PackingGroup: III