PRODUCT Properties
| Melting point: | 124-126℃ |
| Boiling point: | 327.55°C (rough estimate) |
| Density | 1.0583 (rough estimate) |
| refractive index | 1.4300 (estimate) |
| storage temp. | -20°C, Inert atmosphere |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | A light yellow solid |
| pka | 12.50±0.70(Predicted) |
| color | Off-white to yellow |
Description and Uses
Illudins are fungal sesquiterpenes that, through their unique DNA alkylating actions, have anticancer potential. Illudin S is a cytotoxic illudin that is converted, intracellularly, to metabolites that cause a complete block of cell cycling at the G1-S phase interface, particularly in myeloid and T-lymphocyte leukemia cells (IC50 = 6-11 nM). T-lymphocyte leukemia CEM cells that are resistant to doxorubicin , epipodophyllotoxins, and 1-β-D-arabinofuranosylcytosine display only 2-fold increased resistance to illudin S. Illudin S metabolites induce DNA damage that is not repaired by the processes that counter conventional DNA alkylating agents.
Illudin S is a potent antitumor sesquiterpene.
