LN4855249
Reversin121 , ≥98% , 174630-04-7
Synonym(s):
Boc-Asp(Obzl)-Lys(Z)-OtBu
| Pack Size | Price | Stock | Quantity |
| 500ug | RMB332.00 | In Stock |
|
| 1mg | RMB588.00 | In Stock |
|
| 5mg | RMB2016.00 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Boiling point: | 786.8±60.0 °C(Predicted) |
| Density | 1.163±0.06 g/cm3(Predicted) |
| storage temp. | −20°C |
| solubility | DMSO or ethanol: soluble |
| form | powder |
| pka | 10.75±0.46(Predicted) |
| color | white |
Description and Uses
Reversin 121 is a hydrophobic peptide chemosensitizer that can reverse P-glycoprotein-mediated multidrug resistance. It binds to the P-glycoprotein multidrug transporter (MDR1) with a Kd value of 77 nM. Reversin 121 modulates P-glycoprotein ATPase activity in Sf9 insect cell membranes expressing human MDR1, plasma membrane vesicles from multidrug-resistant cells, and reconstituted proteoliposomes as well as in a variety of MDR1-expressing intact tumor cells.
Reversin 121 has been used to determine the activity of P-glycoprotein in human retinal pigment epithelium.
Safety
| WGK Germany | 3 |