13,14-dihydro-15-ketoProstaglandinE1 , ≥98% , 5094-14-4

CAS NO.：5094-14-4

Empirical Formula: C20H34O5

Molecular Weight: 354.49

MDL number: MFCD00135210

PRODUCT Properties

• Boiling point: 537.2±35.0 °C(Predicted)
• Density: 1.072±0.06 g/cm3(Predicted)
• storage temp.: -20°C Freezer, Under inert atmosphere
• solubility: DMSO (Slightly), Methanol (Slightly), THF (Slightly)
• form: Oil
• pka: 4.77±0.10(Predicted)
• color: Dark Yellow

Description and Uses

13,14-dihydro-15-keto Prostaglandin E₁ (PGE₁) is a metabolite of PGE₁ with much reduced biological activity. Steady state plasma concentrations are about 10 pg/ml. 13,14-dihydro-15-keto PGE₁ is a weak inhibitor of ADP-induced platelet aggregation in human PRP and washed platelets with IC₅₀ values of 54 and 200 μM, respectively, compared to PGE₁ which has an IC₅₀ of 40 nM.

15-Keto Prostaglandin E0 is a metabolite of Prostaglandin E1 (P838600) and has been shown to induce arterial thromboresistance in experimental animals and in man, but with several magnitudes higher concentrations than Prostaglandin E1. 15-Keto Prostaglandin E0 is also used as the active ingredient in compositions used for the treatment of external secretion disorders.