17-phenyltrinorProstaglandinF2αcyclopropylmethylamide , ≥98% , 1138395-10-4

CAS NO.：1138395-10-4

Empirical Formula: C27H39NO4

Molecular Weight: 441.6

MDL number:

PRODUCT Properties

• storage temp.: Store at -20°C
• solubility: Acetonitrile: 3 mg/ml; DMF: 25 mg/ml; DMSO: 25 mg/ml; Ethanol: 50 mg/ml; PBS (pH 7.2): .25 mg/ml
• form: A crystalline solid

Description and Uses

Prostaglandin F_2α (PGF_2α) activates the FP receptor, promoting smooth muscle contraction and luteolysis. 17-phenyl trinor PGF_2α binds the FP receptor on ovine luteal cells with a relative potency of 756% compared to that of PGF_2α. It is produced in vivo by the hydrolysis of 17-phenyl trinor PGF_2α ethyl amide. 17-phenyl trinor PGF_2α ethyl amide is used to reduce intraocular pressure related to glaucoma. 17-phenyl trinor PGF_2α cyclopropyl methyl amide is a lipophilic analog of 17-phenyl trinor PGF_2α. Amides of PGs may serve as prodrugs, as they are hydrolyzed in certain tissues to generate the bioactive free acid.

N-Cyclopropyl Methyl Bimatoprost?is a useful reagent for developing methods for treating epithelial-related conditions including hair loss. N-Cyclopropyl Methyl Bimatoprost?is also an analog of?Bimatoprost (B386800), an synthetic prostamide and structurally related to prostaglandin F2α.

Safety

• Symbol(GHS): GHS07,GHS08
• Signal word: Danger
• Hazard statements: H302-H360
• Precautionary statements: P201-P202-P264-P270-P280-P301+P312-P330-P308+P313-P405-P501