FR122047hydrochloride , ≥98% , 130717-51-0

Synonym(s):
1-[(4,5-Bis(4-methoxyphenyl)-2-thiazoyl)carbonyl]-4-methylpiperazine hydrochloride;COX-1 Inhibitor, FR122047 - CAS 130717-51-0 - Calbiochem;FR 122047, 1-[(4,5-Bis(4-methoxyphenyl-2-thiazoyl)carbonyl]-4-methylpiperazine, Hydrochloride, 4,5-Bis(4-methoxyphenyl-2-[(1-methylpiperazin-4-yl)carbonyl]thiazole, Hydrochloride

CAS NO.：130717-51-0

Empirical Formula: C23H26ClN3O3S

Molecular Weight: 459.99

MDL number: MFCD00925604

PRODUCT Properties

• storage temp.: 2-8°C
• solubility: methylene chloride: 50 mg/mL, slightly hazy, yellow
• form: powder
• color: faint yellow
• Water Solubility: Soluble to 10 mM in water

Description and Uses

FR122047 is a selective inhibitor of COX-1. The IC₅₀ values for inhibition of human COX-1 and COX-2 are 0.028 and 65 μM, respectively. In human platelet-rich plasma, FR122047 inhibits arachidonic acid, collagen, and ADP-induced platelet aggregation with an IC₅₀ of 180-200 nM, which is nearly 100 times more potent than aspirin. Unlike aspirin, FR122047 does not induce gastric damage upon oral administration at doses (100 mg/kg) far in excess of the dose needed for complete suppression of platelet COX-1. In some models of inflammation, such as collagen-induced arthritis in the rat, FR122047 has an anti-inflammatory effect, implying a role for COX-1 in these models.

FR 122047 Hydrochloride is a selective cyclooxygenase-1 (Cox-1) inhibitor.

Safety

• Safety Statements: 22-24/25
• WGK Germany: 3