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LN4185849

Nafarelin(acetate) , ≥98% , 86220-42-0

Synonym(s):
5-Oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-3-(2-naphthyl)-D-alanyl-L-leucyl-L-arginyl-L-prolylglycinamide acetate salt hydrate

CAS NO.:86220-42-0

Empirical Formula: C68H89N17O16

Molecular Weight: 1400.54

MDL number: MFCD00895733

Pack Size Price Stock Quantity
500ug RMB588.00 In Stock
1mg RMB1124.00 In Stock
5mg RMB3976.00 In Stock
10mg RMB6880.00 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: >181oC (dec.)
storage temp.  2-8°C
solubility  H2O: >5mg/mL
form  solid
color  white

Description and Uses

Nafarelin acetate is a synthetic decapeptide agonist analog of the natural gonadotropin-releasing hormone, differing in the amino acid at position 6 where D-naphthylalanine has been substituted for glycine. This substitution gives nafarelin greater potency and a substantially longer half-life than the endogenous hormone. Nafarelin acetate administered as a nasal spray, suppresses estrogen levels on repeated dosing and is indicated for the management of endometriosis. It also has orphan drug status for use in precocious puberty.

Nafarelin Acetate is a gonadotropin-releasing hormone agonist. Treatment with Nafarelin improves sleep disturbances and anxiety-depression. Nafarelin is also used in the treatment of estrogen-dependent gynecologic disorders such as endometriosis and uterine leiomyomas.

Safety

WGK Germany  3

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