NafarelinAcetate , ≥98% , 86220-42-0

Synonym(s):
5-Oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-3-(2-naphthyl)-D-alanyl-L-leucyl-L-arginyl-L-prolylglycinamide acetate salt hydrate

CAS NO.：86220-42-0

Empirical Formula: C68H89N17O16

Molecular Weight: 1400.54

MDL number: MFCD00895733

PRODUCT Properties

• Melting point: >181oC (dec.)
• storage temp.: 2-8°C
• solubility: H2O: >5mg/mL
• form: solid
• color: white
• EPA Substance Registry System: Nafarelin acetate (86220-42-0)

Description and Uses

Nafarelin acetate is a synthetic decapeptide agonist analog of the natural gonadotropin-releasing hormone, differing in the amino acid at position 6 where D-naphthylalanine has been substituted for glycine. This substitution gives nafarelin greater potency and a substantially longer half-life than the endogenous hormone. Nafarelin acetate administered as a nasal spray, suppresses estrogen levels on repeated dosing and is indicated for the management of endometriosis. It also has orphan drug status for use in precocious puberty.

Nafarelin Acetate is a gonadotropin-releasing hormone agonist. Treatment with Nafarelin improves sleep disturbances and anxiety-depression. Nafarelin is also used in the treatment of estrogen-dependent gynecologic disorders such as endometriosis and uterine leiomyomas.

Safety

• WGK Germany: 3