R-1Methanandamide , ≥98% , 157182-49-5
Synonym(s):
AM-356;R(+)-Arachidonyl-1′-hydroxy-2′-propylamide
CAS NO.：157182-49-5
Empirical Formula: C23H39NO2
Molecular Weight: 361.56
MDL number: MFCD00467914
EINECS: 200-578-6
| Pack Size | Price | Stock | Quantity |
| 5mg(solution) | RMB460.00 | In Stock |
|
| 10mg(solution) | RMB824.00 | In Stock |
|
| 25mg(solution) | RMB1640.00 | In Stock |
|
| 50mg(solution) | RMB2940.00 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Boiling point: | 529.0±50.0 °C(Predicted) |
| Density | 0.935±0.06 g/cm3(Predicted) |
| RTECS | JX3848000 |
| Flash point: | 14℃ |
| storage temp. | −20°C |
| solubility | DMF: >10 mg/ml; DMSO: >30 mg/ml; Ethanol: >100 mg/ml; Ethanol:PBS (1:2): 8.5 mg/ml; PBS (pH 7.2): <100 μg/ml |
| pka | 14.51±0.10(Predicted) |
| form | Colorless oil. |
| optical activity | [α]/D +8.7°, c = 4 in chloroform(lit.) |
| Sensitive | Air & Light Sensitive |
Description and Uses
R-1 methanandamide is a potent cannabinoid (CB) receptor 1 agonist in the methanandamide series. It is selective for CB1 over CB2 receptors with Ki values ranging from 17.9 to 28.3 and 815 to 868 nM, respectively. R-1 methanandamide is more potent than arachidonoyl ethanolamide (AEA; ). In addition, R-1 methanandamide is more resistant than AEA to hydrolytic inactivation by fatty acid amide hydrolase (FAAH).
Methanandamide is a metabolically stable endocannabinoid analogue of the mammalian brain ligand Anandamide. Methanandamide is known to improve myocardial resistance against arrhythmogenic effects and can also be used to modulate behaviors caused by Amphetamine (HCl: A634248).
Safety
| Symbol(GHS) |   GHS02,GHS07 |
| Signal word | Danger |
| Hazard statements | H315-H335-H225-H319 |
| Precautionary statements | P261-P280a-P304+P340-P405-P501a-P210-P280-P305+P351+P338-P337+P313-P403+P235 |
| Hazard Codes | F |
| Risk Statements | 11 |
| Safety Statements | 7-16 |
| RIDADR | UN 1170 3/PG 2 |
| WGK Germany | 1 |
