AxitinibSulfoxide , ≥98% , 1347304-18-0

CAS NO.：1347304-18-0

Empirical Formula: C22H18N4O2S

Molecular Weight: 402.47

MDL number:

PRODUCT Properties

• Melting point: >225 (dec.)
• Boiling point: 720.6±60.0 °C(Predicted)
• Density: 1.43±0.1 g/cm3(Predicted)
• storage temp.: Refrigerator
• solubility: DMSO (Slightly), Methanol (Slightly, Heated)
• form: Solid
• pka: 11.70±0.40(Predicted)
• color: Light Yellow

Description and Uses

Axitinib sulfoxide is a major inactive metabolite of the tyrosine kinase inhibitor axitinib . It is formed from axitinib primarily by the cytochrome P450 (CYP) isoform CYP3A4 with minor contributions from CYP3A5 and CYP2C19.

Axitinib Sulfoxide is a major metabolite of Axitinib (A794650), a tyrosine kinase inhibitor. Axitinib is used in cancer therapy.

Safety

• Symbol(GHS): GHS07,GHS08
• Signal word: Warning
• Hazard statements: H302-H361
• Precautionary statements: P264-P270-P301+P312-P330-P501-P201-P202-P281-P308+P313-P405-P501